NPTE Pharmacology Practice Test 2025 – All-in-One Guide to Master Your Exam Preparation!

Cushing syndrome is primarily caused by an excess of cortisol in the body, which can result from various factors, including the prolonged use of corticosteroid medications. Corticosteroids mimic the effects of cortisol and are often prescribed for conditions such as inflammatory diseases, autoimmune disorders, and certain cancers. When used in high doses or for extended periods, these medications can lead to an overabundance of cortisol-like effects, contributing to the development of symptoms associated with Cushing syndrome, such as weight gain, hypertension, and changes in skin appearance.

Other medications listed, like diuretics, beta-blockers, and anticoagulants, do not have this association with Cushing syndrome. Diuretics primarily assist in removing excess fluid from the body, beta-blockers are used to manage cardiovascular conditions, and anticoagulants are intended to prevent blood clots. None of these medications are linked to the overproduction of cortisol or the manifestations of Cushing syndrome. Therefore, corticosteroids are the correct answer as they are the medications most commonly associated with this condition.